Source: http://www.sciencenews.org/view/generic/id/62297/title/Muscles_remember_past_glory
The .pdf file of the full PNAS research findings can be downloaded at: http://www.pnas.org/content/early/2010/08/02/0913935107.full.pdf
This interesting story caught my eye this morning. Essentially five scientists from the University of Oslo, Norway (Jo C. Bruusgaard, Ida B. Johansen, Ingrid M. Egner, Zaheer A. Rana, and Kristian Gundersen) have announced their findings in the Proceedings of the National Academy of Science (PNAS) that “Myonuclei acquired by overload exercise precede hypertrophy and are not lost upon detraining,”
In lay speak, while it is common knowledge that the principle “use it or lose it!” applies to exercise and that muscle fibre will atrophy when it is inactive over long periods of time, this research found that muscle fibres retained nuclei substantially longer after overload (training) was discontinued, indeed the scientists even suggested that the presence of this nuclei may also help to delay muscle atrophy.
Where the findings become really interesting for sports lawyers though is in Professor Gunderson et al’s findings on page 3, that contrary to popular opinion, these muscle nuclei do not disappear with the surrounding fibres when the muscle atrophies. “If a hypertrophic episode leads to a lasting higher number of myonuclei, this might provide a long-term advantage even if the stimulus for hypertrophy subsides. The advantage could manifest itself as resistance toward detraining-related atrophy and a more efficient response to retraining.”
And at page 4: “because anabolic steroids facilitate more myonuclei, nuclear permanency may also have implications for exclusion periods after a doping offense.”
This would seem to suggest that the advantages gained from taking performance enhancing substances, particularly anabolic steroids may stay in the body permanently, even when that athlete has demonstrated they are clean after a period of suspension, thereby giving drugs cheats an unfair advantage over other athletes. If these findings are true, they would certainly seem to support the British Olympic Association’s current life ban for Drug Cheats.
It also gives me hope that if my abdomen can somehow remember what a six-pack feels like all those years ago, there is hope for me yet, or at least that’s what I keep telling myself!






Kris is a Senior Lecturer, and Co-Director of the Centre for International Sports Law (CISL) at Staffordshire University, UK. He originally trained and competed as an elite gymnast until a shoulder injury at university forced him to retire as an active competitor. He now spends his spare time coaching Trampolining, Gymnastics, DMT, Cheerleading, Parkour and anything that involves throwing yourself through the air with various degrees of twist and rotation!
Jon is an Associate Professor, and Co-Director of the Centre for International Sports Law (CISL) at Thompson Rivers University, British Columbia. Jon worked as a climbing guide, trained and coordinated search and rescue, managed risk and sales in the United States with a European-based manufacturer of outdoor equipment and advised recreation programmes on their exposure to legal risk. His extra-curricular background is just as diverse and includes stints playing semi-pro volleyball in Brazil, researching wolves in the Canadian Rockies, climbing and leading expeditions from Alaska to Argentina, Tajikistan to the Tetons, and many points in between. He has been married to Wendy for 15 years and together they have 2 wonderful kids – Tegan (10) and Brock (8) – whom he continues to emotionally scar as their football coach!



August 24, 2010
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